Interleukin 21: a cytokine/cytokine receptor system that has come of age

Thioredoxin-thioredoxin reductase--a system that has come of age.

Recent publications make it evident that the thioredoxin± thioredoxin reductase system has come of age. The four minireviews presented here attempt to put this field in perspective. The system was first recognized in the early 1960s as the reductant of methionine sulfoxide and PAPS (3 0-phosphoadenosine-5 0-phosphosulfate) in yeast and of ribonucleotides in Escherichia coli [1±3]. It became cle...

Multimedia Conferencing: Has It Come of Age? Multimedia Conferencing: Has It Come of Age?

Has antifungal susceptibility testing come of age?

The in vitro susceptibility of an infecting organism to the antimicrobial agent selected for therapy is one of several factors that influence the likelihood that therapy for an infection will be successful. To appreciate the value of antifungal susceptibility testing, it is helpful to review the overall predictive utility of antibacterial susceptibility testing. After >30 years of study, in vit...

Has C-Peptide Come of Age?

n this issue, a Consensus Statement on proinsulin Cpeptide is published summarizing the deliberations of an international group of investigators, who met in Detroit in October 2000. This was preceded by the 3rd International Motor City Symposium, the theme of which was concerned with the clinical and biological effects of C-peptide. The abstracts of the presentations at the Symposium are also p...

Transcription factors come of age in lymphoma immunophenotyping: a (T-)bet that has paid off.

In this issue of the Journal, Dorfman and colleagues1 describe the usefulness of T-bet as a marker for specific subtypes of B-cell lymphoma. T-bet originally was identified as a T-box family transcription factor that dominantly programs CD4 and CD8 T-cell development along Th1 and Tc1 pathways, respectively.2 It accomplished this impressive task in part through the coordinated transcriptional a...